There are some uncertainties that will always exist. So it’s not always a question of how to understand things. The question is, given that uncertainties will always be with us, how should we live?
What’s the nature of reality? Can we ever establish a “theory of everything?” Does God exist, and if so, what is God like? There’s so much uncertainly around questions like these. The bigger question isn’t how do we solve them? (though worth exploring) It’s how should we live in spite of them?